Bilberry

Introduction

This fact sheet provides basic information about bilberry—common names, uses, potential side effects, and resources for more information. Bilberry is a relative of the blueberry, and its fruit is commonly used to make pies and jams. It has been used for nearly 1,000 years in traditional European medicine. Bilberry grows in North America, Europe, and northern Asia.

Common Names—bilberry, European blueberry, whortleberry, huckleberry
Latin Names—Vaccinium myrtillus

What It Is Used For

• Historically, bilberry fruit was used to treat diarrhea, scurvy, and other conditions.
• Today, the fruit is used to treat diarrhea, menstrual cramps, eye problems, varicose veins, venous insufficiency (a condition in which the veins do not efficiently return blood from the legs to the heart), and other circulatory problems.
• Bilberry leaf is used for entirely different conditions, including diabetes.

How It Is Used

The fruit of the bilberry plant can be eaten or made into extracts. Similarly, the leaves of the bilberry plant can be made into extracts or used to make teas.

Side Effects and Cautions

• Bilberry fruit is considered safe. However, high doses of bilberry leaf or leaf extract are considered unsafe due to possible toxic side effects.
• Tell your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

Sources

* Bilberry. Natural Medicines Comprehensive Database Web site. Accessed July 2, 2007.
* Bilberry (Vaccinium myrtillus). Natural Standard Database Web site. Accessed June 28, 2007.
* Bilberry fruit. In: Blumenthal M, Goldberg A, Brinckman J, eds. Herbal Medicine: Expanded Commission E Monographs. Newton, MA: Lippincott Williams & Wilkins; 2000:16–21.

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ASTRAGALUS

Introduction

This fact sheet provides basic information about the herbA plant or part of a plant used for its flavor, scent, or potential therapeutic properties. Includes flowers, leaves, bark, fruit, seeds, stems, and roots. astragalus—common names, uses, potential side effects, and resources for more information. Native to China, astragalus has been used for centuries in traditional Chinese medicineA whole medical system that originated in China. It is based on the concept that disease results from disruption in the flow of qi and imbalance in the forces of yin and yang. Practices such as herbs, meditation, massage, and acupuncture seek to aid healing by restoring the yin-yang balance and the flow of qi.. In the United States, the herb gained popularity in the 1980s. There are actually over 2,000 species of astragalus; however, the two related species Astragalus membranaceus and Astragalus mongholicus are the ones primarily used for health purposes.

Common Name—astragalus, bei qi, huang qi, ogi, hwanggi, milk vetch

Latin Name—Astragalus membranaceus, Astragalus mongholicus

What It Is Used For

• Historically, astragalus has been used in traditional Chinese medicine, usually in combination with other herbs, to support and enhance the immune system. It is still widely used in China for chronic hepatitis and as an adjunctive therapy in cancer.
• It is also used to prevent and treat common colds and upper respiratory infections.
• Astragalus has also been used for heart disease.

How It Is Used

The root of the astragalus plant is typically used in soups, teas, extracts, or capsules. Astragalus is generally used with other herbs, such as ginseng, angelica, and licorice.

What the Science Says

• The evidence for using astragalus for any health condition is limited. Results from small or preliminary studies suggest that astragalus may benefit heart function and help the immune system fight infections.
• A few studies have shown potential benefits for using astragalus—in combination with another herb, glossy privet (Ligustrum lucidum)—as an adjunctive therapy for cancer. In general, however, these studies were not well designed.
• NCCAM-funded investigators are studying the effects of astragalus on the body, particularly on the immune system.

Side Effects and Cautions

• Astragalus is considered safe for most adults. Its possible side effects are not well known because astragalus is generally used in combination with other herbs.
• Astragalus may interact with medications that suppress the immune system, such as the drug cyclophosphamide taken by cancer patients and similar drugs taken by organ transplant recipients.
• People should avoid using astragalus species such as "locoweed" that grow in the United States, as these other species may have different effects and side effects.
• Tell your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

Sources
* Astragalus. Natural Medicines Comprehensive Database Web site. Accessed May 10, 2007.
* Astragalus (Astragalus membranaceus). Natural Standard Database Web site. Accessed May 9, 2007.
* Upton R. Astragalus. In: Coates P, Blackman M, Cragg G, et al., eds. Encyclopedia of Dietary Supplements. New York, NY: Marcel Dekker; 2005:25–30

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ASIAN GINSENG

Introduction
This fact sheet provides basic information about the herbA plant or part of a plant used for its flavor, scent, or potential therapeutic properties. Includes flowers, leaves, bark, fruit, seeds, stems, and roots. Asian ginseng—common names, uses, potential side effects, and resources for more information. Asian ginseng is native to China and Korea and has been used in various systems of medicine for many centuries. Asian ginseng is one of several types of true ginseng (another is American ginseng, Panax quinquefolius). An herb called Siberian ginseng or eleuthero (Eleutherococcus senticosus) is not a true ginseng.

Common Names—Asian ginseng, ginseng, Chinese ginseng, Korean ginseng, Asiatic ginseng
Latin Name—Panax ginseng

What It Is Used For
Treatment claims for Asian ginseng are numerous and include the use of the herb to support overall health and boost the immune system. Traditional and modern uses of ginseng include:
Improving the health of people recovering from illness

• Increasing a sense of well-being and stamina, and improving both mental and physical performance
• Treating erectile dysfunction, hepatitis C, and symptoms related to menopause
• Lowering blood glucose and controlling blood pressure

How It Is Used
The root of Asian ginseng contains active chemical components called ginsenosides (or panaxosides) that are thought to be responsible for the herb's medicinal properties. The root is dried and used to make tablets or capsules, extracts, and teas, as well as creams or other preparations for external use.

What the Science Says
Some studies have shown that Asian ginseng may lower blood glucose. Other studies indicate possible beneficial effects on immune function.
To date, research results on Asian ginseng are not conclusive enough to prove health claims associated with the herb. Only a handful of large clinical trials on Asian ginseng have been conducted. Most studies have been small or have had flaws in design and reporting. Some claims for health benefits have been based only on studies conducted in animals.
NCCAM supports studies to better understand the use of Asian ginseng. Areas of recent NCCAM-funded research include Asian ginseng's interactions with other herbs and drugs and the herb's potential to treat chronic lung infection, impaired glucose tolerance, and Alzheimer's disease.

Side Effects and Cautions
When taken by mouth, ginseng is usually well tolerated. Some sources suggest that its use be limited to 3 months because of concerns about the development of side effects.
The most common side effects are headaches and sleep and gastrointestinal problems.
Asian ginseng can cause allergic reactions.
There have been reports of breast tenderness, menstrual irregularities, and high blood pressure associated with Asian ginseng products, but these products' components were not analyzed, so effects may have been due to another herb or drug in the product.
Asian ginseng may lower levels of blood sugar; this effect may be seen more in people with diabetes. Therefore, people with diabetes should use extra caution with Asian ginseng, especially if they are using medicines to lower blood sugar or taking other herbs, such as bitter melon and fenugreek, that are also thought to lower blood sugar.
Tell your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

Sources
Ginseng, Asian (Panax ginseng). In: Coates P, Blackman M, Cragg G, et al., eds. Encyclopedia of Dietary Supplements. New York, NY: Marcel Dekker; 2005:265-277.

Ginseng, Panax. Natural Medicines Comprehensive Database Web site. Accessed on July 2, 2007.

Ginseng. Natural Standard Database Web site. Accessed on June 28, 2007.

Ginseng root. In: Blumenthal M, Goldberg A, Brinckman J, eds. Herbal Medicine: Expanded Commission E Monographs. Newton, MA: Lippincott Williams & Wilkins; 2000:170-177.

National Center for Complementary and Alternative Medicine. Hepatitis C and Complementary and Alternative Medicine: 2003 Update. National Center for Complementary and Alternative Medicine Web site. Accessed on July 9, 2007.

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ALOE VERA

Introduction
This fact sheet provides basic information about aloe vera—common names, uses, potential side effects, and resources for more information. Aloe vera's use can be traced back 6,000 years to early Egypt, where the plant was depicted on stone carvings. Known as the "plant of immortality," aloe was presented as a burial gift to deceased pharaohs.

Common Names—aloe vera, aloe, burn plant, lily of the desert, elephant's gall, lidah buaya
Latin Names—Aloe vera, Aloe barbadensis

What It Is Used For
Traditionally, aloe was used topically to heal wounds and for various skin conditions, and orally as a laxative. Today, in addition to traditional uses, people take aloe orally to treat a variety
of conditions, including diabetes, asthma, epilepsy, and osteoarthritis. People use aloe topically for osteoarthritis, burns, and sunburns. Aloe vera gel can be found in hundreds of skin products, including lotions and sunblocks. The Food and Drug Administration (FDA) has approved aloe vera as a natural food flavoring.

How It Is Used
Aloe leaves contain a clear gel that is often used as a topical ointment.
The green part of the leaf that surrounds the gel can be used to produce a juice or a dried substance (called latex) that is taken by mouth.

What the Science Says
Aloe latex contains strong laxative compounds. Products made with various components of aloe (aloin, aloe-emodin, and barbaloin) were at one time regulated by the FDA as oral over-the-counter (OTC) laxatives. In 2002, the FDA required that all OTC aloe laxative products be removed from the U.S. market or reformulated because the companies that manufactured them did not provide the necessary safety data. Early studies show that topical aloe gel may help heal burns and abrasions. One study, however, showed that aloe gel inhibits healing of deep surgical wounds. Aloe gel does not prevent burns from radiation therapy. There is not enough scientific evidence to support aloe vera for any of its other uses.

Side Effects and Cautions
Use of topical aloe vera is not associated with significant side effects. Abdominal cramps and diarrhea have been reported with oral use of aloe vera. Diarrhea, caused by the laxative effect of oral aloe vera, can decrease the absorption of many drugs.

People with diabetes who use glucose-lowering medication should be cautious if also taking aloe by mouth because preliminary studies suggest aloe may lower blood glucose levels.
Tell your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

Sources
Aloe. Natural Medicines Comprehensive Database Web site. June 5, 2007.
Aloe (Aloe vera). Natural Standard Database Web site. Accessed on June 3, 2007.

For More Information
"What's in the Bottle? An Introduction to Dietary Supplements"
"Herbal Supplements: Consider Safety, Too"
NCCAM Clearinghouse

The NCCAM Clearinghouse provides information on CAM and NCCAM, including publications and searches of Federal databases of scientific and medical literature. The Clearinghouse does not provide medical advice, treatment recommendations, or referrals to practitioners.

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